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  • Title: Studying isoform-specific inositol 1,4,5-trisphosphate receptor function and regulation.
    Author: Betzenhauser MJ, Wagner LE, Won JH, Yule DI.
    Journal: Methods; 2008 Nov; 46(3):177-82. PubMed ID: 18929664.
    Abstract:
    Inositol 1,4,5-trisphosphate receptors (InsP3R) are a family of ubiquitously expressed intracellular Ca2+ channels. Isoform-specific properties of the three family members may play a prominent role in defining the rich diversity of the spatial and temporal characteristics of intracellular Ca2+ signals. Studying the properties of the particular family members is complicated because individual receptor isoforms are typically never expressed in isolation. In this article, we discuss strategies for studying Ca2+ release through individual InsP3R family members with particular reference to methods applicable following expression of recombinant InsP3R and mutant constructs in the DT40-3KO cell line, an unambiguously null InsP3R expression system.
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