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  • Title: Synthesis and pH-dependent micellization of diblock copolymer mixtures.
    Author: Van Butsele K, Sibret P, Fustin CA, Gohy JF, Passirani C, Benoit JP, Jérôme R, Jérôme C.
    Journal: J Colloid Interface Sci; 2009 Jan 15; 329(2):235-43. PubMed ID: 18930246.
    Abstract:
    This work focused on the preparation and the aqueous solution properties of hybrid polymeric micelles consisting of a hydrophobic poly(epsilon-caprolactone) (PCL) core and a mixed shell of hydrophilic poly(ethylene oxide) (PEO) and pH-sensitive poly(2-vinylpyridine) (P2VP). The hybrid micelles were successfully prepared by the rapid addition of acidic water to a binary solution of PCL(34)-b-PEO(114) and PCL(32)-b-P2VP(52) diblock copolymers in N,N-dimethylformamide. These micelles were pH-responsive as result of the pH-dependent ionization of the P2VP block. The impact of pH on the self-assembly of the binary mixture of diblocks-thus on the composition, shape, size and surface properties of the micelles-was studied by a variety of experimental techniques, i.e., dynamic and static light scattering, transmission electron microscopy, Zeta potential, fluorescence spectroscopy and complement hemolytic 50 test.
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