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  • Title: Synthesis and molluscicidal activity of some new thiophene, thiadiazole and pyrazole derivatives.
    Author: Fadda AA, Abdel-Latif E, el-Mekawy RE.
    Journal: Eur J Med Chem; 2009 Mar; 44(3):1250-6. PubMed ID: 18930566.
    Abstract:
    The base-catalyzed reaction of benzoyl acetone 1 with phenyl isothiocyanate yields the non-isolable intermediate 2. Treatment of 2 with dilute HCl afforded the corresponding thiocarbamoyl derivative 3. Reaction of the intermediate 2 with phenacyl bromide, ethyl bromoacetate, chloroacetonitrile, chloroacetyl chloride, bromodiethyl malonate and chloroacetone afforded the corresponding thiophene derivatives 5, 8, 15 and 17. The thiocarbamoyl derivative 3 reacts with arylazophenacyl bromide and/or hydrazine hydrate to afford the corresponding thiadiazole and pyrazole derivatives 20a-c and 22, respectively. These new synthesized compounds show generally a moderate molluscicidal activity to Biomphalaria alexandrina snails.
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