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  • Title: Effect of NMSO3 treatment in a murine model of human metapneumovirus infection.
    Author: Spetch L, Bowlin TL, Casola A.
    Journal: J Gen Virol; 2008 Nov; 89(Pt 11):2709-2712. PubMed ID: 18931066.
    Abstract:
    BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg(-1)) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokine production, suggesting that antiviral treatment initiated at the beginning of viral infection can modify hMPV-induced disease.
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