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  • Title: Effect of varicocelectomy on serum inhibin B levels in infertile patients with varicocele.
    Author: Ozden C, Ozdal OL, Bulut S, Guzel O, Koyuncu HH, Memis A.
    Journal: Scand J Urol Nephrol; 2008; 42(5):441-3. PubMed ID: 18932107.
    Abstract:
    OBJECTIVE: In recent years serum inhibin B level has been proposed as a major indicator for Sertoli cell function and spermatogenesis. This study evaluated the effect of varicocelectomy on serum inhibin B levels and semen parameters in infertile patients with varicocele. MATERIAL AND METHODS: Thirty consecutive patients with varicocele who were complaining of infertility with oligoasthenospermia on sperm analysis were included in the study. All the patients underwent subinguinal varicocelectomy. Spermogram, serum inhibin B levels and hormone analysis were performed at 6-month postoperative follow-up. RESULTS: The mean age of the patients was 24.06+/-3.6 years. There was no statistically significant difference between the mean serum follicle-stimulating hormone, luteinizing hormone, prolactin and testosterone levels of the patients before and after the treatment (p > 0.05). There was a statistically significant improvement in sperm concentration, forward progressive motility and serum inhibin B levels after the treatment (p < 0.05). CONCLUSION: Serum inhibin B level as an endocrine marker combined with a spermogram could provide efficient data for evaluating the effect of varicocelectomy on spermatogenesis.
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