These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease.
    Author: Frisullo G, Nociti V, Iorio R, Patanella AK, Marti A, Cammarota G, Mirabella M, Attilio Tonali P, Batocchi AP.
    Journal: Hum Immunol; 2008 Dec; 69(12):837-9. PubMed ID: 18940217.
    Abstract:
    Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune diseases. We describe a woman affected by a relapsing-remitting demyelinating disease of the central nervous system and occult CD (MS-CD), who showed during neurologic exacerbations a strong increased expression of T-bet, the key transcription factor for the development of Th1 cells, in circulating T, B cells and monocytes. Conversely, no difference of T-bet expression was observed in B cells from relapsing-remitting MS patients, either in relapse or in remission, and in controls. In the MS-CD patient, the interaction between MS- and CD-related inflammatory processes may result in an amplification of Th1 immune response.
    [Abstract] [Full Text] [Related] [New Search]