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  • Title: [Heart failure and cachexia].
    Author: Tabet JY, Meurin P, Ben Driss A, Logeart D, Héliès-Toussaint C, Tartière JM, Cohen-Solal A, Grynberg A, Bourdel-Marchasson I.
    Journal: Arch Mal Coeur Vaiss; 2006 Dec; 99(12):1203-9. PubMed ID: 18942522.
    Abstract:
    Cachexia is related to a malnutrition state related to hypercatabolism. Initially described in cancer, it is also related to several chronic diseases including heart failure. Defined by an unintentional weight loss exceeding 7.5% of body mass during more than 6 months, it is presented by the association of nutritional deficiencies, digestive and/or urinary losses as well as metabolic abnormalities causing fat and lean mass loss and is associated to a poor prognosis. The pathophysiology of cachexia and heart failure presented some similarities associating especially neuro-hormonal activation, a cortisol/DHEA ratio imbalance, as well as pro-inflammatory cytokines activation. Currently the treatment of cachexia is mainly preventive, based on ACE-inhibitors and beta-blockers therapy and physical reconditioning. The benefits of hormonal and nutritional substitutes remains to be evidenced.
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