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  • Title: Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.
    Author: Zhou J, Bhattacharjee A, Chen S, Chen Y, Duffy E, Farmer J, Goldberg J, Hanselmann R, Ippolito JA, Lou R, Orbin A, Oyelere A, Salvino J, Springer D, Tran J, Wang D, Wu Y, Johnson G.
    Journal: Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6175-8. PubMed ID: 18947996.
    Abstract:
    We have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have activity against both linezolid-susceptible and -resistant gram-positive bacteria as well as the fastidious gram-negative bacteria Haemophilus influenzae and Moraxella catarrahalis. The convergent synthesis of these new compounds is detailed.
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