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  • Title: Prognostic factors for recurrence and survival in primary vulvar squamous cell cancer.
    Author: Ayhan A, Velipasaoglu M, Salman MC, Guven S, Gultekin M, Bayraktar O.
    Journal: Acta Obstet Gynecol Scand; 2008; 87(11):1143-9. PubMed ID: 18949585.
    Abstract:
    OBJECTIVE: To evaluate survival estimates and clinico-pathological variables in women with primary vulvar squamous cancer. DESIGN: Retrospective observational study. Setting. University hospital in Turkey. POPULATION OR SAMPLE: Patients treated for primary vulvar squamous cancer. METHODS: Retrospective evaluation of demographic, pathologic and follow-up data of 91 patients obtained from hospital records and private gynecologic oncology files. MAIN OUTCOME MEASURES: Recurrence rate and survival estimates. RESULTS: The mean age at the time of diagnosis was 62 years. Of the women, 62% had early stage disease (stages I-II), while 39% had advanced stages (stages III-IV) at diagnosis. The overall recurrence rate was 13%. Recurrence rates were significantly higher in the presence of local wide-deep excision as an initial treatment, larger initial tumor size, positive lymph node involvement, advanced stage, presence of ulcerative lesions and adjuvant radiotherapy. The overall and 5-year survival estimates were 92 and 83%, respectively. CONCLUSION: Lymph node invasion, stage, having ulcerative lesion, receiving adjuvant therapy, tumor diameter larger than 10 mm and having local excision as primary surgery may increase the risk of recurrent disease.
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