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  • Title: Structure and absolute stereochemistry of the anticancer agent EBC-23 from the Australian rainforest.
    Author: Dong L, Gordon VA, Grange RL, Johns J, Parsons PG, Porzelle A, Reddell P, Schill H, Williams CM.
    Journal: J Am Chem Soc; 2008 Nov 19; 130(46):15262-3. PubMed ID: 18950180.
    Abstract:
    EBC-23 (2), a prostate anticancer agent, was isolated from the fruit of Cinnamomum laubatii (family Lauraceae) in the Australian tropical rainforest. Extensive NOE experiments enabled the relative stereochemistry of the proposed EBC-23 (2) structure to be determined. Total synthesis of both enantiopodes over nine linear steps, involving challenging RCM and spiroacetal cyclizations, confirmed the gross structure and relative and absolute stereochemistry.
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