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  • Title: LDL reduction: how low should we go and is it safe?
    Author: Robinson JG.
    Journal: Curr Cardiol Rep; 2008 Nov; 10(6):481-7. PubMed ID: 18950559.
    Abstract:
    High-dose statin therapy or combination statin treatment is necessary for most patients to achieve aggressive low-density lipoprotein cholesterol goals. Adding ezetimibe or bile acid sequestrants appears unlikely to increase the risk of myopathy. Although the combination of niacin or fenofibrate with moderate-dose statins appears to be reasonably safe, the safety of combination with high-dose statins has yet to be determined. To enhance patient outcomes, attention must be paid to characteristics that predict muscle and hepatic statin toxicity when considering using high-dose statin or combination statin therapy.
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