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  • Title: Nucleotide sequence of the genes encoding the matrix protein of two wild-type measles virus strains.
    Author: Baczko K, Brinckmann U, Pardowitz I, Rima BK, ter Meulen V.
    Journal: J Gen Virol; 1991 Sep; 72 ( Pt 9)():2279-82. PubMed ID: 1895065.
    Abstract:
    The nucleotide sequences of the matrix protein (M) genes of two wild-type measles virus (MV) isolates (JM and CM) have been determined and shown to differ in 56 positions; 31 of these differences are located in the non-coding region and 25 in the coding region of the gene. Most (80%) of the mutations in the coding region are changes to the third base of a codon. A maximum parsimony analysis of the available M gene nucleotide sequences allowed the construction of a tree with at least three lineages or subtypes. One wild-type strain (JM) was very similar to a subacute sclerosing panencephalitis virus strain (case B); the second wild-type strain, CM, showed nucleotide sequence similarity with MV from a case of measles inclusion body encephalitis. Both wild-type virus sequences are distinct from those so far determined for vaccine strains.
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