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  • Title: Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus.
    Author: Matsuda K, Kojima K, Shimakura S, Miura T, Uchiyama M, Shioda S, Ando H, Takahashi A.
    Journal: Comp Biochem Physiol A Mol Integr Physiol; 2009 May; 153(1):3-7. PubMed ID: 18950727.
    Abstract:
    Intracerebroventricular (ICV) administration of melanin-concentrating hormone (MCH) inhibits food intake in goldfish, unlike the orexigenic action in rodents, via the melanocortin system with suppression of neuropeptide Y (NPY) mRNA expression. We therefore investigated the neuronal relationship between MCH- and NPY-containing neurons in the goldfish brain, using a double-immunofluorescence method and confocal laser scanning microscopy. MCH- and NPY-like immunoreactivities were distributed throughout the brain. In particular, MCH-containing nerve fibers or endings lay in close apposition to NPY-containing neurons in a specific region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These observations suggest that MCH-containing neurons provide direct input to NPY-containing neurons in the NPPv of goldfish, and that MCH plays a crucial role in the regulation of feeding behavior as an anorexigenic neuropeptide, inhibiting the orexigenic activity of NPY.
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