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  • Title: Transfusion medicine in a developing country - alloantibodies to red blood cells in multi-transfused patients in Saudi Arabia.
    Author: Gader AG, Al Ghumlas AK, Al-Momen AK.
    Journal: Transfus Apher Sci; 2008 Dec; 39(3):199-204. PubMed ID: 18951063.
    Abstract:
    BACKGROUND: Multiple transfusions are frequently complicated by alloimmunization. This retrospective study aims to determine whether alloimmunization could be accounted for by racial differences between donors and recipients. MATERIALS AND METHODS: The development of alloantibodies were determined in 68 multi-transfused patients (thalassaemia, n=38) and (sickle cell anemia, n=30). RESULTS: The overall frequency of alloantibody formation in our patients is 22.06%. Thirteen patients received blood from the same ethnic group (Arab) and none developed antibodies, while of 47 patients who received multi-ethnic blood, 10 developed alloantibodies. CONCLUSIONS: Alloantibodies formation can be reduced by limiting the transfusion of RBC, collected from donors of the same ethnic origin.
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