These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Increased elevated plus maze open-arm time in mice during spontaneous morphine withdrawal.
    Author: Buckman SG, Hodgson SR, Hofford RS, Eitan S.
    Journal: Behav Brain Res; 2009 Feb 11; 197(2):454-6. PubMed ID: 18955087.
    Abstract:
    Rats undergoing both naloxone-precipitated and spontaneous opioid withdrawal exhibit anxiogenic behaviors in the elevated plus maze (EPM). Recently, we observed an unexpected result, namely mice exhibited increased EPM open-arm time during naloxone-precipitated morphine withdrawal. This was surprising since this behavioral outcome is usually associated with an anxiolytic profile. This study demonstrates that mice exhibit an increase in both EPM open-arm time and % open-arm entries also during spontaneous opioid withdrawal.
    [Abstract] [Full Text] [Related] [New Search]