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  • Title: Effect of an oral adsorbent (AST-120) in rats with daunomycin-induced chronic renal failure.
    Author: Shimizu K, Maeda K, Shibata M, Ise M, Sugano M, Uehara Y.
    Journal: Nihon Jinzo Gakkai Shi; 1991 May; 33(5):507-11. PubMed ID: 1895550.
    Abstract:
    The effect of an oral adsorbent (AST-120) was examined in rats with daunomycin-induced chronic renal failure. Sixteen pairs of daunomycin rats which had similar levels of proteinuria at 4 weeks after being injected with daunomycin were selected. One rat of each pair served as a control and was fed on a standard diet, while the other rats were fed on a diet containing AST-120. The blood creatinine and blood urea nitrogen (BUN) were significantly lower in the rats fed with AST-120 than in the controls. Moreover, the life span of the rats fed with AST-120 was significantly prolonged as compared to that of the control rats. These findings suggest that oral administration of AST-120 may help to prevent rapid deterioration of renal function in experimental chronic renal failure induced by daunomycin in rats.
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