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  • Title: Functional biomimetic models for the active site in the respiratory enzyme cytochrome c oxidase.
    Author: Collman JP, Decréau RA.
    Journal: Chem Commun (Camb); 2008 Nov 07; (41):5065-76. PubMed ID: 18956030.
    Abstract:
    A functional analog of the active site in the respiratory enzyme, cytochrome c oxidase (CcO) reproduces every feature in CcO's active site: a myoglobin-like heme (heme a3), a distal tridentate imidazole copper complex (Cu(B)), a phenol (Tyr244), and a proximal imidazole. When covalently attached to a liquid-crystalline SAM film on an Au electrode, this functional model continuously catalyzes the selective four-electron reduction of dioxygen at physiological potential and pH, under rate-limiting electron flux (as occurs in CcO).
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