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  • Title: Perinatal outcomes after second trimester detection of amniotic fluid viral genome in asymptomatic patients.
    Author: Miller JL, Harman C, Weiner C, Baschat AA.
    Journal: J Perinat Med; 2009; 37(2):140-3. PubMed ID: 18956964.
    Abstract:
    OBJECTIVE: Symptomatic fetal viral infection can affect placental and fetal development and may lead to non-immune hydrops or fetal death. All infections are not detectable by clinical history or ultrasound and a background positivity rate exists in asymptomatic patients. We investigated if intraamniotic presence of viral genome at the time of genetic amniocentesis in asypmtomatic patients affects perinatal outcome. STUDY DESIGN: Six-hundred and eighty-six pregnancies referred for second trimester genetic amniocentesis with a normal ultrasound and fetal karyotype had amniotic fluid multiplex polymerase chain reaction for adeno-, cytomegalo-, Ebstein-Barr-, entero- and parvovirus. Forty asymptomatic patients that were positive for viral genome were matched 2:1 with negative controls. Perinatal outcomes were compared between these groups. RESULTS: Pregnancy complications and perinatal outcomes were similar in the two groups. CONCLUSION: Asymptomatic fetal viral infection at the time of second trimester amniocentesis does not increase the risk for adverse perinatal outcome.
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