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  • Title: On the mechanism of the depressor reaction upon afferent vagal stimulation in cats. II. Role of the beta-adrenergic structures for the development of the depressor reaction.
    Author: Mileva S.
    Journal: Acta Physiol Pharmacol Bulg; 1976; 2(1):30-8. PubMed ID: 189570.
    Abstract:
    Electrical stimulation of the central section of the cervical vagus in cats with bilateral vagotomy results in lowering of the arterial blood pressure. A study is made of the effect of some beta-adrenotropic drugs on the depressor reaction. Propranolol (3 mg/kg i.v.) causes considerable blocking of the depressor reaction in all experiments. On the other hand, Isoprenaline ( a. 10 mug/kh/min) results in a considerable increase of this reaction. The administration of Propranolol (3 mg/kg) and Phentolamine (2 mg/kg) causes almost complete blocking of the reaction. A conclusion is made on the basis of these data that both alpha- and beta-adrenergic structures take part in the realization and development of the depressor reaction upon afferent vagal stimulation.
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