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  • Title: Utility of iodine and 7,7,8,8-tetracyanoquinodimethane for determination of terfenadine.
    Author: Abdel-Hamid ME, Abuirjeie MA.
    Journal: Talanta; 1988 Mar; 35(3):242-4. PubMed ID: 18964505.
    Abstract:
    Simple and sensitive spectrophotometric methods for the assay of terfenadine are described. The first is based on the reaction of terfenadine with iodine to give a molecular charge-transfer complex, the terfenadine acting as an n-electron donor and iodine as a sigma-electron acceptor. The second depends on the formation of a highly coloured stable radical anion between terfenadine and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as a pi-electron acceptor. Beer's law is obeyed over the terfenadine concentration range 0.2-1.2 mg/100 ml. The proposed methods have been successfully applied to the analysis of commercial terfenadine tablets.
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