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  • Title: The use of poly(dimethylsiloxane) surface modification with gold nanoparticles for the microchip electrophoresis.
    Author: Wang AJ, Xu JJ, Zhang Q, Chen HY.
    Journal: Talanta; 2006 Mar 15; 69(1):210-5. PubMed ID: 18970556.
    Abstract:
    Poly(dimethylsiloxane) (PDMS) microfluidic channels modified by citrate-stabilized gold nanoparticles after coating a layer of linear polyethylenimine (LPEI) were successfully used to separate dopamine and epinephrine, which were difficult to be separated from baseline in native and hybrid PDMS microchannels. In-channel amperometric detection with a single carbon fibre cylindrical electrode was employed. Experimental parameters of separation and detection processes were optimized in detail. The analytes were well separated within 100 s in a 3.7 cm long separation channel at a separation voltage of +800 V using a 30 mM phosphate buffer solution (PBS, pH 7.0). Linear responses of them were obtained both from 25 to 600 microM with detection limits of 2 microM for dopamine and 5 microM for epinephrine, respectively. The modified PDMS channels have a long-term stability and an excellent reproducibility within 2 weeks.
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