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  • Title: Reduced serum levels of autoantibodies against monomeric C-reactive protein (CRP) in patients with acute coronary syndrome.
    Author: Wetterö J, Nilsson L, Jonasson L, Sjöwall C.
    Journal: Clin Chim Acta; 2009 Feb; 400(1-2):128-31. PubMed ID: 18973750.
    Abstract:
    INTRODUCTION: Inflammation is pivotal in atherosclerosis. Minor C-reactive protein (CRP) response reflects low-grade vascular inflammation and the high-sensitivity CRP test with levels > or = 3.0 mg/l predicts coronary vascular events and survival in angina pectoris as well as in healthy subjects. We and others recently reported autoantibodies against monomeric CRP (anti-CRP) in rheumatic conditions, e.g. systemic lupus erythematosus (SLE), and a connection between anti-CRP and cardiovascular disease in SLE has been suggested. PATIENTS AND METHODS: Anti-CRP serum levels were determined with ELISA in 140 individuals; 50 healthy controls and 90 patients with angiographically verified coronary artery disease of which 40 presented with acute coronary syndrome (ACS) and 50 with stable angina pectoris (SA). RESULTS: Significantly lower anti-CRP levels were observed in ACS compared to SA and controls (p=0.019). ACS patients, who had not been prescribed statins before their respective cardiovascular event, had lower anti-CRP (p=0.049). BMI correlated directly to anti-CRP levels in cross section analysis (p=0.043), but there was no association between anti-CRP and smoking or cholesterol. DISCUSSION: In ACS, it is plausible that ruptured plaques and inflamed tissue may be more prone to opsonization by monomeric CRP leading to consumption of anti-CRP. Hypothetically, surface-bound anti-CRP could thereby enhance the local inflammation in plaques.
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