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  • Title: Cytotoxic T cells in the peritoneal cavity of mice infected with ectromelia virus.
    Author: Pang T, Gardner ID, Blanden RV.
    Journal: Aust J Exp Biol Med Sci; 1976 Aug; 54(4):365-70. PubMed ID: 189743.
    Abstract:
    Peritoneal exudate cells from mice infected with ectromelia virus were cytotoxic for virus-infected target cells as measured in a 51Cr release assay. Cytotoxic activity seemed to be T cell-dependent as it was largely abolished by treatment with anti-theta serum and complement but was not impaired by macrophage depletion. The kinetics of development of cytotoxicity in the peritoneal cavity lagged behind spleen cytotoxicity by 1-2 days. Peak activity in peritoneal cells was present about 6 days after intravenous infection with virus. These studies suggest that macrophages present in the free peritoneal cell populations of ectromelia-infected mice are not cytotoxic for virus-infected target cells. The effect of macrophages in virus clearance is therefore likely to be due to phagocytic rather than cytotoxic effects.
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