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  • Title: [Research on the background correction in the non-invasive sensing of glucose by near-infrared spectroscopy].
    Author: Liu R, Gu XY, Xu KX.
    Journal: Guang Pu Xue Yu Guang Pu Fen Xi; 2008 Aug; 28(8):1772-5. PubMed ID: 18975800.
    Abstract:
    For the non-invasive blood glucose concentration sensing by the near-infrared spectroscopy, the signal to noise ratio of the optical measurement system is very low. Both the content of glucose in body and the absorption coefficient of glucose in the near-infrared region are quite weak. More over, the structure of spectral noise is complicated and the variation of noise intensity is very large. The background correction is one of the most effective pre-processing methods to improve the signal to noise ratio of the near-infrared optical detection system. In this paper, the theory expression formula of traditional background correction method was induced firstly. Then in order to avoid the influence from the variation of optical characteristics in the sample and the drift in the optical system, the similar background correction method was proposed, that is, the background which has the similar optical characteristics with the sample was chosen as the reference. The in vitro experiments of pure absorption media and scattering media were conducted to validate the effect. The results showed that, for the glucose in the blood plasma solution and Intralipid-2% solution, after the correction of the background which has the similar optical characteristics with the sample, the prediction precision of multivariate model for glucose concentration has been improved by 25.9% and 40.1%, respectively.
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