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  • Title: Specific interaction of TFII-I with an upstream element on the HIV-1 LTR regulates induction of latent provirus.
    Author: Malcolm T, Kam J, Pour PS, Sadowski I.
    Journal: FEBS Lett; 2008 Nov 26; 582(28):3903-8. PubMed ID: 18976654.
    Abstract:
    RBF-2 is a factor comprised of a USF1/2 heterodimer, whose association with a highly conserved upstream element (RBEIII) on the HIV-1 LTR requires a co-factor TFII-I. We have identified specific nucleotides, immediately 3' of RBEIII that are required for stable association of TFII-I with this region of the LTR. Mutations that inhibit interaction of TFII-I with DNA also prevent stimulation of USF binding to RBEIII, and render the integrated LTR unresponsive to T cell signaling. These results demonstrate an essential role of TFII-I bound at an upstream LTR element for viral replication.
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