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Title: Can NK cells be a therapeutic target in human cancer? Author: Chan CJ, Andrews DM, Smyth MJ. Journal: Eur J Immunol; 2008 Nov; 38(11):2964-8. PubMed ID: 18979512. Abstract: Our current knowledge of NK-cell recognition and effector function suggests that it will be possible to design various new NK-cell-based immunotherapies against human cancer. The application of NK cells is already showing promise using HLA-mismatched haematopoietic stem cell transplantation for treatment of haematological malignancies. A better understanding of NK-cell heterogeneity and function will only broaden the applications for human cancer. Here we review the key developments that will propel this field.[Abstract] [Full Text] [Related] [New Search]