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  • Title: [The association of tyrosine hydroxylase gene polymorphism with mental disorder].
    Author: Yu J, Pang H, Wang BJ.
    Journal: Fa Yi Xue Za Zhi; 2008 Oct; 24(5):333-5. PubMed ID: 18979915.
    Abstract:
    OBJECTIVE: To evaluate the relationship between the tyrosine hydroxylase (TH) gene and mental disorder by comparing the two TH gene SNP points (extron 3 and intron 9) of patients with mental disorders and normal human. METHODS: DNA extracted from specimens of patients and normal subjects were quantified by using Real-time PCR. RESULTS: (1) G334A distribution was: G=0.133, A=0.867 in patients with schizophrenia, G=0.116, A=0.884 in patients with depression, and G=0.214, A=0.786 in normal group. (2) C5162G distribution was: C=0.962, G=0.038 in patients with schizophrenia, C=0.959, G=0.041 in patients with depression, and C=0.961, G=0.039 in normal group. CONCLUSION: There are statistically significant differences in G334A locus between normal people and patients with mental disorders, but no statistically significant differences in C5162G locus.
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