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  • Title: Pleomorphic fibroma of skin. A case report and immunohistochemical study.
    Author: Layfield LJ, Fain JS.
    Journal: Arch Pathol Lab Med; 1991 Oct; 115(10):1046-9. PubMed ID: 1898234.
    Abstract:
    An immunohistochemical study of a clinically benin but cytologically atypical mesenchymal lesion of the skin is presented. This lesion has been previously reported as pleomorphic fibroma and was shown to follow a benign course with a potential for local recurrence. These lesions contain occasional markedly atypical enlarged spindle cells with anaplastic-appearing nuclei. Nonmirror image mitotic figures may be present. Histogenesis of this neoplasm remains controversial with a fibroblastic origin being favored by previous authors. Our immunohistochemical findings would support this conclusion.
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