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  • Title: Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
    Author: Minkkilä A, Saario SM, Käsnänen H, Leppänen J, Poso A, Nevalainen T.
    Journal: J Med Chem; 2008 Nov 27; 51(22):7057-60. PubMed ID: 18983140.
    Abstract:
    A series of commercial phenyl-, heteroaryl-, alkyl-, and alkenylboronic acids were evaluated for their FAAH and MGL inhibitory activities. The compounds were generally selective for FAAH, with IC50 in the nanomolar or low-micromolar range. Eight of these compounds inhibited MGL with IC50 in the micromolar range. The most potent compound, phenylboronic acid with para-nonyl substituent (13), inhibited FAAH and MGL with IC50 of 0.0091 and 7.9 microM, respectively.
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