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Title: Developmental changes in the organization of the nuclear lamina in mouse liver. Author: Pandey S, Parnaik VK. Journal: Biochem Biophys Res Commun; 1991 Sep 16; 179(2):1082-7. PubMed ID: 1898389. Abstract: We have compared the organization of the nuclear lamina in adult and fetal mouse liver. Western blot analysis of the expression of lamins with specific antibodies indicates that lamin B is expressed throughout liver development, unlike lamins A and C which are absent in fetal liver. Using [125I]lamin in blot binding assays, we have observed that lamin B binds to at least three membrane proteins (96, 54 and 34 kDa) and to lamins A and C in adult nuclear envelopes, but only to the 54 and 34 kDa proteins and lamin B itself in fetal nuclear envelopes, where lamin B appears to be hyperphosphorylated.[Abstract] [Full Text] [Related] [New Search]