These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Binding of radioiodinated SPECT ligands to transfected cell membranes expressing single muscarinic receptor subtypes.
    Author: Zeeberg BR, Gitler MS, Baumgold J, de la Cruz RA, Reba RC.
    Journal: Biochem Biophys Res Commun; 1991 Sep 16; 179(2):768-75. PubMed ID: 1898398.
    Abstract:
    The equilibrium dissociation constant and the kinetic rate constants were determined for the binding of (R)-[3H]3-quinuclidinyl benzilate ([3H]QNB) and [125I]3-quinuclidinyl-4-iodobenzilate ((R,R)- and (R,S)-[125I]IQNB) to transfected cell membranes expressing one single muscarinic acetylcholine receptor (mAChR) subtype. The association and dissociation kinetics for the m2 subtype were more rapid than for the m1 and m3 subtypes. The differential kinetic properties may be useful for the single photon emission computed tomographic (SPECT) evaluation of regional mAChR subtype alterations in disease states.
    [Abstract] [Full Text] [Related] [New Search]