These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Transient myeloproliferative disorder in neonates with and without Down syndrome: a tale of 2 syndromes.
    Author: Apollonsky N, Shende A, Ouansafi I, Brody J, Atlas M, Aygun B.
    Journal: J Pediatr Hematol Oncol; 2008 Nov; 30(11):860-4. PubMed ID: 18989165.
    Abstract:
    Transient myeloproliferative disorder (TMD) in newborns with Down syndrome (DS) has been well described. We report 4 newborns, 2 with DS and 2 without DS, who developed TMD. One newborn with DS developed multiorgan failure and died despite treatment with low-dose cytarabine. In 3 newborns, the TMD resolved spontaneously. Two of these patients, 1 with and 1 without DS developed leukemia on subsequent follow-up and were treated successfully. We reviewed the clinical and laboratory data on 14 non-DS infants with TMD reported in the literature. According to limited data, these patients are more likely to develop leukemia than DS patients, however their outcome is better.
    [Abstract] [Full Text] [Related] [New Search]