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  • Title: Antimicrobially active isoquinoline alkaloids from Litsea cubeba.
    Author: Feng T, Xu Y, Cai XH, Du ZZ, Luo XD.
    Journal: Planta Med; 2009 Jan; 75(1):76-9. PubMed ID: 18991207.
    Abstract:
    Bioassay-guided fractionation of the alkaloidal extract of the aerial part of Litsea cubeba led to the isolation of two new isoquinoline alkaloids, (+)- N-(methoxycarbonyl)-N-norboldine (1) and (+)-isoboldine beta-N-oxide (2), together with 11 known analogues (3-13). Their structures were established by extensive spectroscopic techniques and by comparing spectroscopic data with those in the literature. Compounds 1 and 4 showed antimicrobial activities. This is the first report on the presence of compounds 1, 2, 6, 8, 9, 11, and 12 in this plant and on the antimicrobial activities of 1 and 4. The bioactivities of isoquinoline alkaloids are also at least partly responsible for the pharmacological function of the folk medicinal plant Litsea cubeba.
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