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  • Title: Alpha 1-antitrypsin deficiency: pathogenesis and treatment.
    Author: Crystal RG.
    Journal: Hosp Pract (Off Ed); 1991 Feb 15; 26(2):81-4, 88-9, 93-4. PubMed ID: 1899256.
    Abstract:
    Inherited defects of the gene coding for a serum protein that protects alveolar walls from proteolysis constitute one cause of emphysema, with or without liver disease. The deficiency can be reversed with intravenous administration of the antiprotease, keeping serum levels above the minimum needed for lung protection.
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