These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Beta-C-glycosiduronic acids and beta-C-glycosyl compounds: new PTP1B inhibitors.
    Author: Lin L, Shen Q, Chen GR, Xie J.
    Journal: Bioorg Med Chem Lett; 2008 Dec 15; 18(24):6348-51. PubMed ID: 18993066.
    Abstract:
    Beta-C-glycosiduronic acid quinones and beta-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl beta-C-glycosyl compounds (18, 22, 23 and 34) showed IC(50) values of 0.77-5.27 microM against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent.
    [Abstract] [Full Text] [Related] [New Search]