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  • Title: A variant translocation t(2;18) in follicular lymphoma involves the 5' end of bcl-2 and Ig kappa light chain gene.
    Author: Hillion J, Mecucci C, Aventin A, Leroux D, Wlodarska I, Van Den Berghe H, Larsen CJ.
    Journal: Oncogene; 1991 Jan; 6(1):169-72. PubMed ID: 1899478.
    Abstract:
    We have examined three cases of human lymphoma bearing a t(2;18)(p11;q21) chromosome translocation. The bcl-2 gene appeared to be rearranged in all three cases and breakpoints were clustered in the 5' flanking region of the gene. In all three cases, bcl-2 was juxtaposed to J segments of the Ig kappa gene. This juxtaposition of the bcl-2 and Ig kappa genes is very similar to the variant chromosome translocations of Burkitt lymphoma that juxtapose the c-myc locus to IgL genes.
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