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  • Title: [Multihospital randomized study on pre- and post-operative adjuvant chemotherapy for colorectal cancer (Part 2)].
    Author: Ishikawa H, Tomita M, Shimoyama T, Hirano T, Nakagoe T, Shimizu T, Kusano H, Eida K, Ishii T, Kotake Y.
    Journal: Gan To Kagaku Ryoho; 1991 Feb; 18(2):277-82. PubMed ID: 1899550.
    Abstract:
    Prior to surgery, 400 mg/day of UFT was administered for seven days to 86 patients with colorectal cancer. After surgery, the survival rate and side effects of the MMC only group (group A) and the MMC + UFT group (group B) were investigated. The two year survival rate for all cases was 79.8% for group B as opposed to 67.1% for group A. The two year survival rate for cases of histological curative resection were 80.0% for group A and 91.4% for group B, but the difference was not significant. There were few side effects in either group, and a significant difference in the incidence was not observed. Based on the above, MMC combined with UFT, as adjunctive chemotherapy for colorectal cancer, is considered to be a safe and effective treatment.
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