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  • Title: Detection of miR-106a in gastric carcinoma and its clinical significance.
    Author: Xiao B, Guo J, Miao Y, Jiang Z, Huan R, Zhang Y, Li D, Zhong J.
    Journal: Clin Chim Acta; 2009 Feb; 400(1-2):97-102. PubMed ID: 18996365.
    Abstract:
    BACKGROUND: MicroRNAs (miRNAs) play important roles in carcinogenesis. miRNA-106a (miR-106a) has oncogenic activity in humans, and often has altered expression. The clinical significance of miR-106a in the diagnosis of gastric carcinoma is poorly understood. METHODS: The level of miR-106a in 55 gastric carcinoma and 17 non-tumor tissues was quantified by real-time reverse transcriptase-polymerase chain reaction, and the relationship between miR-106a level and clinical and pathological factors was explored. RESULTS: The level of miR-106a in cancer tissues was significantly higher than that in non-tumor tissues, with an average 1.625-fold increase. miR-106a level was significantly associated with tumor stage, size and differentiation; lymphatic and distant metastasis; and invasion (P<0.01). The altered expression of miR-106a was confirmed in gastric cancer cell lines. CONCLUSION: miR-106a may be a potential biomarker in the diagnosis of gastric carcinoma.
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