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  • Title: Epidermal growth factor-induced expression of c-fos is influenced by altered gravity conditions.
    Author: de Groot RP, Rijken PJ, Boonstra J, Verkleij AJ, de Laat SW, Kruijer W.
    Journal: Aviat Space Environ Med; 1991 Jan; 62(1):37-40. PubMed ID: 1899994.
    Abstract:
    Epidermal growth factor (EGF) activates a well characterized signal transduction system in human A431 epidermoid carcinoma cells, which leads to rapid and transient expression of the c-fos proto-oncogene. In order to investigate the influence of altered gravity on EGF-induced signal transduction, we have studied the EGF-induced c-fos expression under simulated hypo- and hypergravity conditions. In this report we show that EGF-induced fos expression is decreased under simulated hypogravity conditions, while hypergravity has a stimulatory effect on EGF-induced fos expression. These results show that the EGF-activated signal transduction system is influenced by gravity, and that gravity exerts its effects already in the early phases of the signal transduction cascade.
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