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  • Title: Predictors to assess non-sentinel lymph node status in breast cancer patients with sentinel lymph node metastasis.
    Author: Jinno H, Sakata M, Asaga S, Wada M, Shimada T, Kitagawa Y, Suzuki T, Nakahara T, Kitamura N, Kubo A, Mukai M, Ikeda T, Kitajima M.
    Journal: Breast J; 2008; 14(6):551-5. PubMed ID: 19000054.
    Abstract:
    The next step of sentinel lymph node biopsy (SLNB) in breast cancer is to determine which patients need axillary lymph node dissection (ALND) following a positive SLNB. A prospective database of 239 patients who underwent SLNB followed by complete ALND at Keio University Hospital from January 2001 to June 2005 was reviewed. A total of 131 patients with one or more positive sentinel lymph nodes (SLNs) were further analyzed. A univariate analysis showed a significant correlation between non-SLN involvement and lymphatic invasion, vascular invasion, number of tumor-involved SLNs, radioactivity of SLNs, and size of SLN metastasis (p = 0.0002, p = 0.004, p = 0.006, p = 0.04, p = 0.03, respectively). By multivariate analysis, lymphatic invasion and the number of tumor-involved SLNs remained significant predictors of non-SLN involvement. In breast cancer patients with a positive SLN, lymphatic invasion and the number of tumor-involved SLNs were both independent predictors of non-SLN involvement.
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