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  • Title: Plugging gp120s cavity.
    Author: Repik A, Clapham PR.
    Journal: Structure; 2008 Nov 12; 16(11):1603-4. PubMed ID: 19000812.
    Abstract:
    NBD-556 is a class of HIV-1 entry inhibitors that binds HIV-1 surface glycoprotein gp120 and induces conformational changes, which mimic those caused by CD4 binding. Here, Madani et al. (2008) show that NBD-556 binds to the highly conserved "Phe-43 cavity" on gp120.
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