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  • Title: A new class of reversible cell cycle inhibitors.
    Author: Hoffman BD, Hanauske-Abel HM, Flint A, Lalande M.
    Journal: Cytometry; 1991; 12(1):26-32. PubMed ID: 1900227.
    Abstract:
    The effects of three compounds on the cell cycle of HL-60 promyeloid leukemia cells has been examined. Ciclopirox olamine, an antifungal agent, and the compound Hoechst 768159 reversibly block the cell cycle at a point occurring roughly 1 h before the arrest mediated by aphidicolin, an inhibitor of DNA polymerase alpha activity, which acts in early S phase. Similar results are also obtained with the compound mimosine, a plant amino acid. Based on these data, it is concluded that all three agents inhibit cell cycle traverse at or very near the G1/S phase boundary and identify a previously undefined reversible cell cycle arrest point.
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