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  • Title: Are there sex-related differences in responses to repetitive olfactory/trigeminal stimuli?
    Author: Scheibe M, Opatz O, Hummel T.
    Journal: Eur Arch Otorhinolaryngol; 2009 Aug; 266(8):1323-6. PubMed ID: 19002476.
    Abstract:
    Sex differences in olfactory sensitivity have been reported since the late 1800's with women typically outperforming men on tests of odor detection, discrimination or identification. It is not known whether women adapt differently than men to olfactory and trigeminal stimuli. Seventeen healthy volunteers participated (9 female, 8 male, mean age 22 years) in the study. As established by an odor identification test (UPSIT, score > or =38) all subjects had normal olfactory function. Event-related potentials (ERPs) were recorded in response to olfactory (25% v/v phenyl ethyl alcohol) and trigeminal (44% v/v CO(2)) stimuli using a computer controlled olfactometer (flow 8 L/min; stimulus duration 200 ms). Stimuli were applied at four intervals (5, 10, 20, and 60 s). Amplitudes and latencies of ERP peaks P1, N1, and P2 were measured. Stimulus intensity also rated using visual analogue scales subjects. When compared to phenyl ethyl alcohol, the slightly more intense CO(2) produced larger amplitudes and shorter latencies. Both, ratings and ERP amplitudes P2 decreased with decreasing interval between stimuli. Responses to the trigeminal and olfactory stimuli changed similarly in relation to repetitive stimulation. Women had larger ERP amplitudes P2. No sex-related difference for ratings and ERP in relation to repeated stimulation amplitudes was observed. Although women exhibit larger ERP amplitudes to chemosensory stimuli compared to men, the present data indicate on both psychophysical and electrophysiological levels that there is no major difference between young, healthy men and women in relation to short-term adaptation to suprathreshold chemosensory stimulation.
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