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  • Title: Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.
    Author: Leifert JA, Bossaller L, Uhl M.
    Journal: Vasa; 2008 Nov; 37(4):374-8. PubMed ID: 19003750.
    Abstract:
    Accidental intra-arterial injection of drugs is a sporadic complication in i.v. drug addicts. A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg. Severe rhabdomyolysis developed within 5 hours after the injection. Selective arterial catheter angiography showed an acute occlusion of the posterior tibial artery. Combination therapy with i.a. urokinase, i.a. prostaglandines and i.v. anticoagulation resulted in re-opening of the obstructed distal artery and complete cessation of symptoms.
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