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  • Title: Higher implantation rate using modified quarter laser-assisted zona thinning in repeated implantation failure.
    Author: Debrock S, Spiessens C, Peeraer K, De Loecker P, Willemen D, D'Hooghe TM.
    Journal: Gynecol Obstet Invest; 2009; 67(2):127-33. PubMed ID: 19005260.
    Abstract:
    BACKGROUND/AIMS: Some embryo implantation problems in patients with recurrent implantation failure may be explained by the inability of the embryo to hatch out of its zona pellucida. In this case-control study, a study group which had received modified quarter laser-assisted zona thinning (mQLAZT) was compared with a control group which had not received mQLAZT with respect to reproductive outcome. METHODS: Cycles from patients with a 4th fresh embryo transfer (ET) after 3 previously failed ET cycles (no beta-hCG detected) were included. Cases (group A, n = 53) included ET cycles from patients who received a 4th ET with fresh embryos after mQLAZT. Controls (group B, n = 86) included ET cycles from patients who had a 4th ET without mQLAZT. The clinical implantation rate and live birth rate per embryo transferred were measured. RESULTS: The clinical implantation rate with positive fetal heart beat per embryo transferred was significantly higher (p = 0.035) in group A (22/107 or 21%) than in group B (18/166 or 11%). CONCLUSION: The data of this case-control study suggest that mQLAZT can be effective in the treatment of patients with recurrent implantation failure, but need to be confirmed by randomized trials.
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