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  • Title: Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with clear cell endometrial cancer.
    Author: Richey DS, Welch BJ.
    Journal: South Med J; 2008 Dec; 101(12):1266-8. PubMed ID: 19005452.
    Abstract:
    A 65-year-old Caucasian woman with a known history of clear cell endometrial cancer presented with hypercalcemia. Further evaluation demonstrated that the patient had primary hyperparathyroidism due to a parathyroid adenoma, as well as an increased parathyroid hormone-related peptide secondary to her malignancy. To the best of our knowledge, this is the first reported case of a female patient with concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy. This case illustrates the importance of considering a broad differential when evaluating patients with hypercalcemia. It also emphasizes the importance of recognizing the biochemical interplay between parathyroid hormone and parathyroid hormone-related peptide.
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