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  • Title: Isolation and characterization of nitrogen mustard-sensitive mutants of Chinese hamster ovary cells.
    Author: Meyn RE, Murray D, vanAnkeren SC, Bernard GS, Mellard DN, Hobbs ML.
    Journal: Mutat Res; 1991 Mar; 254(2):161-5. PubMed ID: 1900571.
    Abstract:
    Three nitrogen mustard-sensitive lines of Chinese hamster ovary cells were isolated from mutagenized cultures using the procedure of Thompson et al. (1980). The lines, designated NM1, NM2 and NM3, were 2.1-, 17- and 6.8-fold more sensitive to nitrogen mustard, respectively, than their parent, wild-type, line as determined by the dose required to kill 90% of the cells, IC90. Patterns of cross-sensitivity to other DNA-damaging agents including ultraviolet light, cis-diamminedichloroplatinum, and other alkylating agents were determined for each line. Analysis of these results suggests that the phenotypes of the mutant lines are different from those lines reported previously.
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