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  • Title: Electrophysiological recording from parasitic nematode muscle.
    Author: Robertson AP, Puttachary S, Buxton SK, Martin RJ.
    Journal: Invert Neurosci; 2008 Dec; 8(4):167-75. PubMed ID: 19005711.
    Abstract:
    Infection of man and animals with parasitic nematodes is recognized as a significant global problem (McLeod in Int J Parasitol 25(11):1363-1367, 1994; Hotez et al. in N Engl J Med 357(10):1018-1027, 2007). At present control of these infections relies primarily on chemotherapy. There are a limited number of classes of anthelmintic compounds and the majority of these act on ion-channels of the parasite (Martin et al. in Parasitology 113:S137-S156, 1996). In this report, we describe electrophysiological recording techniques as applied to parasitic nematodes. The aim of this report is: (1) to promote the study of ion channels in nematodes to help further the understanding of antinematodal drug action; (2) to describe our recording equipment and experimental protocols; and (3) provide some examples of the information to be gleaned from this approach and how it can increase our understanding of these important pathogens.
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