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  • Title: Total synthesis of (-)-agelastatin A.
    Author: Yoshimitsu T, Ino T, Tanaka T.
    Journal: Org Lett; 2008 Dec 04; 10(23):5457-60. PubMed ID: 19006318.
    Abstract:
    A new route to (-)-agelastatin A is reported. The requisite nitrogen functionalities of the agelastatin core have been installed by intramolecular aziridination of an azidoformate and subsequent regioselective azidation, leading to net trans-diamination of the double bond. The present synthesis also demonstrates two new protocols for the preparation of an imidazolidinone hemiaminal motif from an oxazolidinone intermediate which comprise sequential N-tert-butoxycarbonylation, urea formation, hydrolysis, and oxidative cyclization, and direct aminolysis and subsequent oxidative cyclization.
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