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  • Title: Vilsmeier reaction of enaminones: efficient synthesis of halogenated pyridin-2(1H)-ones.
    Author: Zhang R, Zhang D, Guo Y, Zhou G, Jiang Z, Dong D.
    Journal: J Org Chem; 2008 Dec 05; 73(23):9504-7. PubMed ID: 19006368.
    Abstract:
    A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.
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